Oral Presentation The 44th Lorne Conference on Protein Structure and Function 2019

The Joy of Seeing – in Honour of Dorothy Hodgkin ***Georgina Sweet awardee (#4)

Eleanor Dodson 1
  1. University of York, Heslington, United Kingdom

To quote Dorothy Hodgkin: The great advantage of X-ray analysis as a method of chemical structure analysis is its power to show some totally unexpected and surprising structure and to do so with absolute certainty.

I will show examples of how Fourier analysis using X-ray observations from a crystal, combined with imperfect phases, can allow us to boot-strap our way to a satisfactory structure. Combining these basic principals with the great computing power, and excellent data acquisition facilities now available has extended our power to “see” to new levels.

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  2. Carlisle, C. H.; Crowfoot, D. (1945). "The Crystal Structure of Cholesteryl Iodide". Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences. 184 (996): 64
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  8. Sheldrick, G.M. (2010). "Experimental phasing with SHELXC/D/E: combining chain tracing with density modification", Acta Cryst D66, 479-485.
  9. A. Thorn and Sheldrick, G.M. (2013) Extending molecular-replacement solutions with SHELXE. Acta Cryst D69, 2251-2256.