Wednesday, 13th February The 44th Lorne Conference on Protein Structure and Function 2019

• Cellular consequences of systematic perturbations of a highly conserved biological switch protein ***Protein Society Speaker - Tanja Kortemme
• Protein engineering through tandem transamidation - Robert E. Thompson
• SLAM-FRET provides insights into the conformational landscape of human Argonaute 2 - Dina Grohmann
• Coupling directed evolution with NMR to probe ligand induced changes in α_1A-adrenoceptor conformational equilibria and characterize fragment screening hits - Daniel J Scott
• Evaluation and extension of the two-site, two-step model for binding and activation of chemokine receptor CCR1 - Martin J Stone

• Structure and dynamics of large protein complexes involved in human transcription initiation ***Grimwade Medal awardee - Eva Nogales
• The structure and activity of the mRNA decapping complex inside and outside of cytoplasmic processing bodies. - Remco Sprangers
• A new role for the neuronal cytokine S100B: Suppression of amyloid-beta aggregation - Vanessa K Morris
• Towards the mechanisms of chromatin transcription - Patrick Cramer

• Allosteric regulation of RING E3 ligases - Helen Walden
• Functional proteomics for understanding the assembly and breakdown of mitochondrial machines in health and disease - David A Stroud
• Design and application of novel chemical probes to detect cathepsin X activation in oral cancer - Laura E Edgington-Mitchell
• Ubiquitin signals in mitophagy - David Komander

Jacqui Matthews & Danny Hatters