Tuesday, 12th February The 44th Lorne Conference on Protein Structure and Function 2019
Breakfast
7:30AM - 8:30AM
Tuesday, 12th February
Lorne Central
Session 8: Pathogens and Disease
8:30AM - 10:30AM
Tuesday, 12th February
Auditorium
Chairs: James Whisstock & Miroslaw Cygler
- Trim-Away: Targeted degradation of pathogens and proteins by the cytosolic antibody receptor TRIM21 - Leo James
- The structural basis of selective metal ion transport in pathogenic bacteria - Christopher McDevitt
- The conformational state of the MLKL protein tightly regulates necroptotic cell death - Emma J Petrie
- Single particle cryo-EM analysis of the multidrug efflux pump TriABC from Pseudomonas aeruginosa. - Isabelle Rouiller
- Old proteins - a field in its infancy - Roger Truscott
Morning Tea/Coffee Break
10:30AM - 11:00AM
Tuesday, 12th February
Exhibition Hall
Session 9: Macromolecular Complexes
11:00AM - 1:00PM
Tuesday, 12th February
Auditorium
Chairs: Melissa Call & Chandrika Deshpande
- MicroED: conception, practice and future opportunities. - Tamir Gonen
- Structural insights into the activation of the adenosine A1 receptor - Christopher J Draper-Joyce
- Single-molecule visualisation of protein dynamics in the eukaryotic replisome. - Lisanne M. Spenkelink
- The EMBO Keynote Lecture. Protein synthesis: from ribosome assembly to targeting of membrane proteins ***EMBO keynote speaker - Nenad Ban
Lunch
1:00PM - 4:00PM
Tuesday, 12th February
Exhibition Hall
Synchrotron Users Group Meeting
1:15PM - 2:15PM
Tuesday, 12th February
Auditorium
Sponsored by:
Student and Invited Speaker Lunch (Ticketed Event)
1:10PM - 4:00PM
Tuesday, 12th February
Horizons Room
Session 10: Poster Session C including refreshments (Note Odd / Even Rules)
4:00PM - 6:00PM
Tuesday, 12th February
Exhibition Hall
- Effect of pH in the structural integrity of Green Fluorescent Protein (GFP) - Nathalia V. dos Santos
- Cryo-EM structures of YenTc: changing paradigms of host interaction in pore-forming ABC toxins - Sarah Piper
- Engineering a FRET-based biosensor for visualising hippocampal D-serine - Vanessa Vongsouthi
- Studying MLKL’s interaction with the plasma membrane using giant unilamellar vesicles as a model system - Katherine Anne Davies
- Investigation of the underlying activities and mechanisms of chromodomain helicase DNA binding protein 4 (CHD4) - Jessica Zhong
- Molecular evolution of imipenem resistance in clinical isolates of Klebsiella - Natalia Rosas Bastidas
- New oligosaccharide mimetic inhibitors of heparanase - Cassidy Whitefield
- Biophysical characterization of survivin interactions - Maja Jensen
- When ligand meets protein: Structural characterisation of apolipoprotein-D during lipid interaction - Claudia S Kielkopf
- How and why do small heat-shock proteins inhibit amyloid formation? - Emily Selig
- Targeting the mitochondria during Coxiella burnetii infection - Laura F Fielden
- Rad6-18, the master regulator of translesion synthesis - Brittany M Ripley
- Investigating the role of proteostasis pathways in regulating the intracellular protein aggregation of firefly luciferase - Shannon McMahon
- Investigating how small heat shock proteins prevent protein aggregation using single-molecule fluorescence microscopy - Caitlin Johnston
- Investigating the contribution of legumain to oral cancer pain - Bethany M Anderson
- Enhancing the biophysical properties of a1-antitrypsin - Emilia Marijanovic
- Structure guided treatment approach for tuberculosis - Malancha Karmakar
- Structural characterisation of the antimicrobial protein BSAP-4 from the gut symbiont Bacteroides vulgatus/dorei species - Bronte A Johnstone
- An AIE-active probe for intracellular protein carbonylation detection - Siyang Ding
- Molecular basis for the folding of the autotransporter Ag43 passenger domain - Xiaojun Yuan
- New enzyme architecture: an investigation on the evolution of super-Long form ATP-PRTase - Parastoo Khajeaian
- Enzyme choreography during lesion skipping at the E. coli replication fork - Gurleen Kaur
- Structural and functional characterisation of MlaD from Acinetobacter baumannii - Jing Zhang
- Design a Sensor detecting Protein Aggregation in Human Cell Endoplasmic Reticulum - Soheila Sabouri
- Structural characterisation of mitochondrial Complex IV assembly factors - Shadi Maghool
- Investigating a common structural element in T- and B-cell antigen receptor transmembrane assembly - Samyuktha Ramesh
- PulA of type II secretion system plays a role in the virulence of Klebsiella pneumoniae - Yajie Zhao
- Investigating the interaction between nascent Httex1 and ribosomes. - Poly Talukdar
- Nuclear bodies formed by polyQ-ataxin-1 protein are liquid RNA/protein droplets with tunable dynamics - Sunyuan Zhang
- Monoubiquitination locks FANCI:FANCD2 on DNA to initiate DNA repair - Winnie Tan
- Mechanistic differences in DNA binding behaviour of Isl1/Lhx3 homeodomains in transcriptional complexes - Ngaio Smith
- Controlled construction of cyclic D/L peptide nanorods - Mitchell R Silk
- Real-time single-molecule visualisation of CMG helicase dynamics at roadblocks on DNA - Stefan H Mueller
- mCSM-PPI2: Predicting the effects of single-point mutations in protein-protein interactions - Carlos HM Rodrigues
- A revised biosynthetic pathway for cofactor F420 in bacteria - James Antoney
- Identification of natural ligands of, and their mode of interaction with ABC-transporter substrate-binding protein DppA of Helicobacter pylori - Mohammad Mizanur Rahman
- LPP mediated periplasmic architecture plays a significant role in lipoprotein regulated peptidoglycan assembly - Eric L Mandela
- Backbone dynamics of the N-terminal domain of Neisserial DsbD - Stefan Nebl
- Single-molecule imaging of DNA polymerase II in live Escherichia coli cells: housekeeping and DNA damage-induced activities - Thomas Armstrong
- Unifying the Serpin phylogeny: relationships in protein sequence, structure and function - Matthew Spence
- Structure and dynamics of fusion protein linkers - Joshua A Mitchell
- Identifying functionally important features within protein tertiary structures using the Missense Tolerance Ratio - Michael Silk
- Understanding the evolutionary path leading to the diversification of glycopeptide antibiotics. - Mathias Hansen
- Investigating mechanisms of T cell receptor activation - Nick Chandler
- Characterization and engineering of the PET degrading enzyme MHETase - Jake Saunders
- Investigating the pathogenesis of Sengers syndrome, a mitochondrial disease caused by mutations in the mitochondrial Acylglycerol Kinase, AGK - Thomas Jackson
- Modulation of apoptosis by the E3 ligase Parkin - Jonathan Bernardini
- Developing a protein folding-sensor to study molecular chaperone function at the single-molecule level. - Nicholas R Marzano
- Solving the annotation puzzle: Using substrate-binding proteins to redefine nutrient acquisition in cyanobacteria - Benjamin A. Ford
- Exploring three KH domains of hnRNPK in complex with single-stranded nucleic acids - Brian Le
- Understanding the role of the Scribble PDZ domains in cell polarity regulation - Ivan How
- Evolutionary tuning of chromophore absorption and energy transfer in photosynthetic light harvesting proteins - Harry W Rathbone
- Molecular architecture of the E. faecalis anti-termination protein EutV bound to RNA - James L Walshe
- Encapsulins as platforms for enzyme-based nanoreactors - Lachlan S.R. Adamson
- Interrogating the function of hTim8b in human mitochondria - Alex Anderson
- Identification of mechanisms involved in the toxicity of misfolded proteins and proteostasis imbalance - Viacheslav Kriachkov
- RHIM-based functional amyloid assemblies in viral evasion of host cell death - Max ODG Baker
- The role of functional amyloid in the human necroptosis cascade and its modulation by viruses - Nirukshan Shanmugam
- F420H2-dependent reductases promiscuously catalyze selective dihydrogenation of activated alkenes - Suk Woo Kang
- ATP binding causes loss of entropy & function-shifting conformational changes in the bicarbonate transport regulatory protein, SbtB, from Cyanobium sp. PCC 7001. - Joe A Kaczmarski
- Structural and functional characterisation of two interacting pseudokinase scaffolds - Ashleigh Kropp
- Functional characterisation of HIGD1A and HIGD2A and their roles in the assembly of mitochondrial respiratory chain - Daniella H Hock
- The Diverse Roles of Paraspeckle Components - Joanne Coyle
- Investigating the RNA binding specificity of Drosophila behaviour/human splicing proteins - Yee Seng Chong
- Determinants of Macrocycle Permeability - Billy J Williams-Noonan
- Novel peptide inhibitors of the master stress regulator HSF1 - Joseph Polidano
Dinner (own arrangements)
6:00PM - 7:45PM
Tuesday, 12th February
Session 11: Robin Anders Young Investigators Award session
7:45PM - 9:00PM
Tuesday, 12th February
Auditorium
Chairs: Bostjan Kobe & Urmi Dhagat
- Three distinct modes of CRISPR-Cas12a inactivation - Gavin J. Knott
- Proteostasis pathways in the mechanism of action of artemisinin, a Nobel Prize-winning antimalarial - Jessica L Bridgford
- Constructing synthetic organelles from self-assembling protein nanocompartments - Yu Heng Lau
- Structural and functional analysis of COA7, an essential component of the mitochondrial complex IV assembly machinery - Luke E Formosa
- The translocase of the inner membrane 22: a modern view of a mitochondrial insertase - Yilin Kang
Session 12: Poster Session D - Including Happy Hour & Trade Display
9:00PM - 10:00PM
Tuesday, 12th February
Exhibition Hall
- RNA inhibits the methyltransferase activity of the Polycomb repressive complex 2 (PRC2) through interactions with an exposed regulatory site - Qi Zhang
- Single-molecule visualization of Saccharomyces cerevisiae leading-strand synthesis reveals dynamic interaction between MTC and the replisome - jacob S lewis
- Single molecule investigation of transcription coupled repair - Harshad Ghodke
- Understanding the roles of subunits and assembly factors implicated in the biogenesis of human Complex II - Joanna Sacharz
- Conformational changes in E. coli ATP synthase structure on exposure to ATP - Meghna Sobti
- The molecular mechanism of manganese import in Streptococcus pneumoniae - Alex R. Carey Hulyer
- A chaperone binding peptide with therapeutic potential against cancers - Chi-Lung Lee
- Antibiotic influx through porins from the outer membrane of Klebsiella pneumoniae - Andrea Rocker
- Apoptosis in the mite Sarcoptes scabiei - Jason M Brouwer
- Characterization of the binding of endogenous and exogenous ligands to prostanoid biosynthesis-related enzymes by computational solvent mapping - Inseok Song
- Ensemble properties of BAX determine its function - Adeline Y Robin
- The National Deuteration Facility: isotopic labelling of proteins for structure function applications. - Karyn L Wilde
- Quantifying protein stability at the proteome-wide scale - Dezerae Cox
- Multiple personalities: competitive binding of NuRD subunits can lead to distinct functions - Jason KK Low
- Investigating the potential role of MARCH proteins in regulating the Notch signalling pathway - Cyrus Tan
- The Nucleosome Remodelling and Deacetylase (NuRD) complex has an asymmetric, dynamic and modular architecture - Ana PG Silva
- Catabolic AMP-Activated Protein Kinase (AMPK) is Regulated by Anabolic Mechanistic Target of Rapamycin (mTOR) - William J. Smiles
- The murine cytomegalovirus M45 protein interacts with necroptosis-associated proteins to form heteromeric amyloid assemblies. - Chi L. L. Pham
- The Non-Ribosomal Peptide Synthetase Ebony Encodes a Novel Type of Condensation Domain - Thierry Izoré
- Novel insight into the assembly of complex III (coenzyme q - cytochrome c – oxidoreductase) - Boris Reljic
- Characterisation of the novel flagella-tropic bacteriophage YSD1 - Rhys A Dunstan
- Periplasmic assembly of β-lactamases - Grishma Vadlamani
- A multimeric form of the bacterial chaperone SurA - Rebecca S Bamert
- Characterisation of mortise-tenon joints in outer membrane proteins and their influence on β-barrel stability - Matthew D Johnson
- Structural analysis of phosphorylation-associated interactions of MCC to Scribble PDZ domains - Bryce Stewart
- A haem binding protein produced by Haemophilus haemolyticus inhibits non-typeable Haemophilus influenzae - David Gell
- HOIP RBR E3 ubiquitin ligase activity is differentially regulated by linear ubiquitin and HOIL-1L - Bernhard C. Lechtenberg
- New Ideas in Customer-centric CryoEM Automated Collection, Workflows, and Processing for High-resolution Protein Structures - Simon HJ Brown
- Structural characterisation of Doublecortin-like kinase 1, a microtubule-binding protein - Onisha Patel
- Transcriptomic changes in Escherichia coli during overexpression of the translocation and assembly module (TAM). - Chaille T Webb
- Towards a mechanistic understanding of ezrin activation upon binding lipid - Neil O. Robertson
- The HIV-1 capsid protein interacts with novel components of the nuclear pore complex - Claire F Dickson
- Elucidating the role lipids play in the oligomerization and aggregation dynamics of α-synuclein - Blagojce Jovcevski
- Multi-functional Dye System for Visualising Unfolded Proteins in Cells - Tze Cin Owyong