Monday, 11th February The 44th Lorne Conference on Protein Structure and Function 2019

• Development of Peptide and Peptidomimetic Therapeutic Agents from a New Zealand Perspective   - Margaret Brimble
• The evolution of nitroimidazole antibiotic resistance in Mycobacterium tuberculosis - Brendon Lee
• The β₂-clamp as a novel antimicrobial target - Amy E McGrath
• Regulation of CARD9-mediated BCL-10 nucleation  - Wayne Fairbrother

• Molecular visualization with Unity and Vuforia - Michael Kuiper
• The cryo-EM structure of the endocytic receptor DEC205 reveals a conformational control-mechanism for antigen detection by dendritic cells - Richard Berry
• World’s smallest viral capsid structure: A robust and targeted delivery platform for the biomedically important cargo - Subir Sarker
• Understanding Piezo1's Relationship with Lipids - Amanda Buyan
• Membrane protein insertion through the lateral gate of TamA - Christopher J Stubenrauch
• “Open sesame”: fragments crack open a cryptic pocket on a challenging protein-protein interaction target - Geqing Wang
• The molecular basis of JAK/STAT inhibition by SOCS1 - Nicholas PD Liau
• Structure of a Signalling Cannabinoid Receptor 1-G Protein Complex - Kaavya Krishna Kumar

• RaPID peptide library screening for the discovery of selective and high affinity bromodomain inhibitors - Joel Mackay
• Measuring the kinetics of PROTAC ternary complexes. - Michael J Roy
• Acquired BCL2 mutations that confer resistance to Venetoclax treatment - Richard W Birkinshaw
• Peptide Inhibitors of the Kv1.3 Potassium Channel for the Treatment of Autoimmune and Other Inflammatory Diseases - Raymond Norton
• Soaking it all in: accelerating hit-to-lead generation through screening of unpurified reaction mixtures using X-Ray crystallography - Olga V Ilyichova
• Refining the model for ligand-dependent differential receptor:effector coupling through single molecule studies. - Sebastian GB Furness

• Development of the plant defensin, HXP124, as a safe and effective treatment for fungal nail infections - Nicole L Van Der Weerden
• Rational targetting of the Signal Recognition Particle Receptor - Lorna Wilkinson-White
• The importance of being assayed: design, synthesis and biological evaluation of isoquinolines as antimalarial agents - Belinda M Abbott
• Finding the Achilles' Heel in Multi-Drug Resistant Gram-Negative Bacteria - Tatiana P. Soares da Costa
• Targeting branched chain amino acid biosynthesis for the development of new antifungals to treat human pathogenic infections - Luke Guddat
• Can humanised bacterial LeuT be used to study the pharmacology of human B⁰AT1 (SLC6A19)? - Nishank Shah
• Elucidating the structural basis of PPARg antagonism to inform design of improved drugs to treat T2DM - Rebecca Frkic
• Determination of Ligand Binding Conformations at α₁-Adrenergic Receptor Subtypes Based on NMR - Tasneem M. Vaid
• An engineered microbial system for deciphering the molecular functions of tryptophan C-mannosylation - Alan John

Membranes Matter: Predicting Drug Toxicity - R. Lea Sanford
Can humanised bacterial LeuT be used to study the pharmacology of human B⁰AT1 (SLC6A19)? - Nishank Shah
Elucidating the structural basis of PPARg antagonism to inform design of improved drugs to treat T2DM - Rebecca Frkic
Determination of Ligand Binding Conformations at α₁-Adrenergic Receptor Subtypes Based on NMR - Tasneem M. Vaid
An engineered microbial system for deciphering the molecular functions of tryptophan C-mannosylation - Alan John

• Using protein structural information as a predictor of rifampicin resistance in tuberculosis - Stephanie Portelli
• Refil an efficient workflow for early stage hit to lead optimisation - Beatrice Chiew
• SOX18 Interactome: Clinical Hypotrichosis-lymphedema-telangiectasia-renal defect (HTLRS) is revealing the SOX18 code - Paulina Rudolffi
• Reconstitution of teicoplanin biosynthesis as a platform for the redesign of non-ribosomal peptide synthesis - Milda Kaniusaite
• Design of a “minifrag” library for the identification of protein hot spots by x-ray crystallography - Rebecca Whitehouse
• RECOMBINANT EXPRESSION OF A PROBLEMATIC PROTEIN - Larissa Doughty
• Antibody Recognition of a Polysaccharide Common to Many Microbes and Biofilms - Caroline Soliman
• Crystal structures of an unusual transcriptional activator from bacteriophage 186 - Jia Q Truong
• Mass spectrometry approaches for the structural characterisation of class III Biotin Protein Ligases; novel antifungal drug targets - Louise M Sternicki
• Reactive oxygen species promote DNA polymerase IV activity in Escherichia coli - Sarah Henrikus
• Evolution on the microscope: Examining the role of translesion synthesis in the development of ciprofloxacin resistance - Megan E Cherry
• Exploring the effect of mutations on structure-function relationship of cd93 by molecular dynamics simulations   - Vittoria Cicaloni
• Structural analysis of critical interactions in the replication machinery of rabies virus - Jingyu Zhan
• Expression, Purification and Structural Characterisation of TACAN: a Novel Mechanosensitive Channel - Nazanin Mohebali
• A C-terminal fragment of chlorotoxin retains bioactivity and inhibits cell migration - Mohadeseh Dastpeyman
• Intrinsic Fluorescence Spectroscopy And Molecular Modelling Lead To The Development Of New Tyrosyl-DNA Phosphodiesterase 1​ Inhibitors - Jinal Patel
• Structure and mechanism of H2 relaxin binding to its receptors - Shatabdi Chakraborty
• Characterization of ACA-01 - a novel chemokine-binding tick evasin   - Sayeeda Chowdhury
• RaPID Selection of Structurally Diverse and High Affinity Cyclic Peptide BET Bromodomain Inhibitors - Karishma Patel
• The molecular chaperone alphaB-crystallin still retains functionality in inhibiting protein aggregation after cross-linking with the oxidative stressor, dopamine - Junna Hayashi
• Exploring the binding sites of human ATP- Binding Cassette B5 transporter by molecular docking - Lokeswari Prathyusha Tangella
• Probing the reaction mechanism and inhibition of Mtu-AnPRTase enzyme: a potential target to novel antimicrobial drug design. - Preeti Kundu
• Studying the interaction between the phosphatase PTP1B and the Janus Kinases - Rhiannon Morris
• Structural and functional characterisation of the BCL-2 family member BCL-rambo - Kristen Scicluna
• Structural and functional characterisation of the epigenetic regulator, SMCHD1 - Alexandra D Gurzau
• Dynamin structure and function hinging on Ryngos - David A Cardoso
• Grouper Iridovirus GIV66 is a Bcl-2 protein that inhibits apoptosis by exclusively sequestering Bim - Suresh Banjara
• Engineering a non-antibody scaffold to bind therapeutic targets - Peter G Chandler
• Understanding the role of the innate immune system in Alzheimer's and Parkinson’s disease - Jasmina Markulic
• Development of small molecule inhibitors of pathogenic and functional amyloid associated with human and plant diseases - Sarah R Ball
• Tracking ligand induced changes in the conformational equilibrium of a_1A-adrenergic receptor using NMR - Feng-Jie Wu
• Development of binding and activity assays for phosphatidylcholine-specific phospholipase C - Nabangshu Sharma
• mCSM-ABv2: an in silico tool for antibody affinity maturation - YooChan Myung
• A structural investigation of NRZ mediated apoptosis regulation in zebrafish - Chathura Suraweera
• Characterising the roles of two receptor tyrosine pseudokinases, EphA10 and EphB6, in cancers - Lung-Yu Liang
• A Maleimide-functionalized Tetraphenylethene Structural Analog for Measuring Protein Unfolding in Cells - Shouxiang Mr Zhang
• Understanding the architecture, assembly, and interactome of the nucleosome remodelling and deacetylase (NuRD) complex - Mehdi Sharifi Tabar
• Structural and functional characterisation of the muscle-specific regulatory subunit of AMPK - Ashley Ovens
• High electric field induced structural changes in protein complexes - Per Börjesson
• Exploring the dynamics of the site-specific mutator effector system, pEvolvR, on rescuing the activity of a defective chloramphenicol acetyltransferase protein - Minh MT Nguyen Tran
• The fate of nucleic acids in membraneless organelle models   One shape fits all - Alain AM André
• Molecular evolution of multi-specificity in the sirtuin-1 family of proteins - Mahakaran Sandhu
• The C. elegans TRIM protein NHL-2 and its role in the let-7 miRNA pathway - Rhys Colson
• The structure of the Plasmodium falciparum 20S proteasome in complex with the PA28 activator. - Riley D Metcalfe
• Coherent diffractive imaging of microtubules using an X-ray laser - Greger Hammarin
• Developing a FRET-based RNA biosensor.  - Brady A Johnston
• Pregnancy can be a stressful time especially for proteins - Jordan H. Cater
• Protein-protein interaction between molecular chaperones and amyloid fibrils - Alexis Z Minchaca
• Aromatic prenyltransferases as key diversity generating enzymes in the synthesis of secondary metabolites - Rudranuj Bundela
• Parallel solid phase synthesis: an efficient strategy for the fragment based drug design of novel HIV-1 reverse transcriptase inhibitors - Shane L Dawson
• Single-molecule methods to probe the coordination of E. coli DNA replication - Richard Spinks
• Rapid Elaboration of Fragments into Leads (REFiL) as applied to BRD3-ET - Luke A Adams
• Visualising “invisible” states of proteins to support fragment-based drug design - Biswaranjan Mohanty
• Fragment screening against stabilized α_1A and α_1B adrenoceptors allows identification of novel sub-type selective antagonist - Alaa Abdul-Ridha
• Suppressive effects of SG-SP1 on mast cell-mediated allergic inflammation via regulation of FceRI signaling - Sang-Hyun Kim
• Creating an Australian cGMP facility to produce proteins for clinical trials - George Lovrecz
• Identification of small molecules exhibiting oxacillin synergy through direct inhibition of VraS and inhibition of vraSTR expression in methicillin resistant Staphylococcus aureus - Michael E Johnson

• Structural studies of the M₅ muscarinic acetylcholine receptor - Ziva Vuckovic Muller
• Rapid Elaboration of Fragments into Leads (REFiL). A systematic approach to fragment elaboration. - Menachem J Gunzburg
• Calcium is a required cofactor for metal efflux by the ferroportin transporter family - Chandrika N Deshpande
• Tracing the origin of the nucleosome the structure of archaeal chromatin - Sudipta Bhattacharyya
• SOX18 mutations associated with human HLTRS syndrome reveal modification of protein-protein interactions - Mehdi MM Moustaqil
• The complex mode of agonist binding and activation of the relaxin GPCR, RXFP1. - Ashish Sethi
• Single Particle CryoEM to aid in next generation antibiotic discovery. - Matthew Belousoff
• Protein Production and Characterisation - Mario Torrado del Rey
• Application of Innovative, Automated Workflows to Cardiac Ischemia Biomarker Discovery and Multiomics Data Visualization. - Scott Kuzdzal
• Structural venomics: evolution of a complex chemical arsenal by massive duplication and neofunctionalization of a single ancestral fold - Yanni KY Chin
• Understanding the structural basis for endotoxin recognition and neutralization - Peter J Bond
• High resolution cryo-EM structure of a disease-associated variant of the AAA ATPase p97 - Sepideh Valimehr
• Kinetic and crystallographic studies reveal potent new AMPK inhibitor, SBI-0206965, is a highly selective Type IIb kinase inhibitor - Chris G Langendorf
• Strategies to inhibit beta common receptor mediated signalling using small molecules and monoclonal antibodies. - Urmi Dhagat
• An aggregation-induced emission (AIE) active fluorogen for assessing unfolded proteins in stressed cells - Mengjie (Oscar) Liu
• Molecular basis for regulation of antibiotic biosynthesis by 2-alkyl-4-hydroxymethylfuran-3-carboxylic acids - Hussain Dr Bhukya
• Tandem Domain Evasins: Inhibitors of Chemokine-mediated Inflammation - Ram P. Bhusal
• Understanding the ligand-selective nuclear hormone receptor activation by fatty acid-binding protein 1 - Indu R. Chandrashekaran
• Rutinosidase - Labyrinthine Journey for X-ray Structure - Petr Pachl
• A biosensor based FLIM-FRET phasor approach to measure proteostasis capacity in cells - Nagaraj S Moily
• Transition state analysis of Clostridium difficile TcdB toxin - Ashleigh S Paparella
• Understanding the mechanisms of hERG channel gating and drug inhibition using cryo-EM - Carus Lau
• Human β-defensin 2 kills Candida albicans through phosphatidylinositol 4,5-bisphosphate–mediated membrane permeabilization - Michael A Järvå
• Structural biology in 4D: Cryo-EM structures of the Yersinia entomophaga toxin complex reveal structural transitions that underpin pore-formation and toxin translocation - Michael Landsberg
• Cryo-EM Studies of Machines on Genes: DNA Replication and Recombination Complexes - Gökhan Tolun
• Viral MLKL homologs subvert necroptotic cell death by sequestering cellular RIPK3 - James M Murphy
• Cryo-EM analysis of filamentous chaperonins - Alastair Stewart
• The α subunits of light harvesting proteins from cryptophyte algae tune the absorbance spectrum of the complex and determine the quaternary structure. - Katharine A Michie
• Understanding the function of RECQL4 in DNA replication and genome maintenance - Vince J Murphy
• Protein aggregation and neuroinflammation are related in Alzheimer’s disease - Daniel R Whiten
• Structural, mechanistic, and evolutionary insights into sulfoglycolysis - James P Lingford
• Investigating the role of conformational change in gating and conduction of K_IR K⁺ channels - Katrina Black
• Structural basis of RNA polymerase I transcription - Christoph Engel